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32 Dossiers van huisgenoten werden bestudeerd op gemeenschappelijke kenmerken. In 15 gevallen ging het om de echtgenote, in 11 om de dochter van de man die met asbest had gewerkt. Het betrof 27 gevallen van longvlies- en 5 gevallen van buikvlieskanker. De latentietijd was in 27 gevallen langer dan 40 jaar geweest.

Bron: Miller, Albert (2005). American journal of industrial medicine. vol. 47, afl. 5, pag. 458-462 (5)

Mesothelioma in household members of asbestos-exposed workers : 32 United States cases since 1990

Miller, Albert / In: American journal of industrial medicine. vol. 47 (2005), afl. 5, pag. 458-462 (5) / 2005

Abstract

Background

Mesothelioma is significant as an indicator of asbestos exposure, as a continuing major cause of death in those exposed, and as a risk following lesser exposures. One such exposure is living in the household of an asbestos worker, and coming into contact with fibers brought home on his/her body, clothing, etc.

Methods

Law firms throughout the US known for their pursuit of asbestos claims were polled for mesothelioma claims brought on behalf of family members of identifiable asbestos-exposed workers. Cases with any occupational, environmental, or other possible exposure were not included.

Results

This study reports 32 household-exposure mesothelioma cases, diagnosed since 1990. Relationships were wife (15), daughter (11), son (3), sister-in law (1), niece (1), and boarder (1). Occupations of the workers included shipyard (13), insulator (7), and other (12). Of the 27 pleural cases, 13 were epithelial, 5 fibrous, 3 biphasic, and 6 not specified. of the 5 peritoneal cases, 4 were epithelial and 1 fibrous. Latency was greater than 40 years in 27 cases. 6 cases were 40-49 years of age and 17 were 60 or older.

Conclusions

Records from law firms were a useful source of information. Mesothelioma resulting from household exposure is a continuing problem. It is more likely to present in the elderly, after latencies of >40 years. Am. J. Ind. Med. 47:458-462, 2005.

Onderzoek onder een cohort van 889 mannen en 1077 vrouwen die tussen 1946 en 1984 minimaal 1 maand hadden gewerkt voor een voormalig belangrijk asbest(textiel)bedrijf in Italië. De onderzoekers constateerden een directe relatie tussen de asbestblootstellingsduur en de incidentie van asbestgerelateerde longkanker en buikvlieskanker. Er was geen directe relatie tussen de blootstellingsduur en incidentie van longvlieskanker. Zelfs onder werknemers die korter dan een jaar voor het bedrijf hadden gewerkt was de incidentie van longvlieskanker veel hoger dan gemiddeld. Bron: British Journal of Cancer 2005, 92.
Cancer mortality in a cohort of asbestos textile workers

E Pira1, C Pelucchi*,2, L Buffoni1, A Palmas1, M Turbiglio1, E Negri2, PG Piolatto1 and C La Vecchia2,3

A cohort of 889 men and 1077 women employed for at least 1 month between 1946 and 1984 by a former Italian leading asbestos (mainly textile) company, characterised by extremely heavy exposures often for short durations, was followed up to 1996, for a total of 53 024 person-years of observation. Employment data were obtained from factory personnel records, while vital status and causes of death were ascertained through municipality registers and local health units. We observed 222 cancer deaths compared with 116.4 expected (standardized mortality ratio, SMR-191). The highest ratios were found for pleural (SMR-4105), peritoneal (SMR-1817) and lung (SMR-282) cancers. We observed direct relationships with duration of employment for lung and peritoneal cancer, and with time since first employment for lung cancer and mesothelioma. Pleural cancer risk was independent from duration (SMR-3428 for employment o1 year, 7659 for 1-4 years, 2979 for 5-9 years and 2130 for X10 years). Corresponding SMRs for lung cancer were 139, 251, 233 and 531. Nonsignificantly increased ratios were found for ovarian (SMR-261), laryngeal (SMR-238) and oro-pharyngeal (SMR-226) cancers. This study confirms and further quantifies the central role of latency in pleural mesothelioma and of cumulative exposure in lung cancer.

British Journal of Cancer (2005) 92, 580-586. doi:10.1038/sj.bjc.6602240 www.bjcancer.com

& 2005 Cancer Research UK

Keywords: asbestos. cancer mortality. cohort study. lung cancer. mesothelioma

Onderzoeker Burdorf en collega’s vroegen zich af of er een verband is tussen blootstelling aan asbest in het milieu en pleuramesothelioom (longvlieskanker) onder vrouwen. In een onderzoek in Hof van Twente, waar op grote schaal asbestafval is gebruikt voor de verharding van erven en wegen, constateerden zij een oversterfte aan pleuramesothelioom bij vrouwen. Bron: Nederlands Tijdschrift voor Geneeskunde, nr 35, bl. 1727, 28 augustus 2004.